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Phytosphingosine
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ADCs Toxins, Phytosphingosine is a sphingolipid endogenous to many organisms involved in cell signaling. Phytosphingosine displays anbibacterial activity (CL Fischer et al. Antimicrob. Agents Chemother. 2012 56:1157). Phytosphingosine can be taken up by E. coli and S. aureus and induce ultrastrucural damag (CL Fischer et al. Skin Pharmacol. Physiol. 2013 26:36). IC 50 value: Jurkat (Acute leukemic T-cells): IC50 = 3.75 µM (human). pKa: 11.91 (Predicted), pKb: 7.98 (Predicted). https://www.creative-biolabs.com/adc/classify-adc-toxins-6.htm
