Non-cleavable Linker

Creative Biolabs can provide several noncleavable alkyl and polymeric linkers, such as the notablely successful MCC amine-to-sulfhydryl bifunctional cross-linker featured in T-DM1. This linker is especially useful as the cyclohexane ring provides steric hindrance that decreases the rate of hydrolysis of the resulting thioether. Non-cleavable thioether linkers, succinimide-thioether bonds that formed by the reaction of maleimids with thiols, have also been commonly used to link auristatin derivatives to monoclonal antibodies. Creative Biolabs has extensive experience in providing design and selection of non-cleavable linkers for antibody-drug conjugate (ADC) development. https://www.creative-biolabs.com/adc/non-cleavable-linker.htm