Venomous™ Thermal Anti-Wrinkle Serum is a proprietary roll-on that targets lines, puffiness and age spots in one unique formula, and it retails for $29.99. This is the ultimate wrinkle serum featuringCapsaicin hot pepper extract and Syn-Ake®, a rare triple peptide (Waglerin 1), found only in the venom of the Asian Temple Viper. Syn-Ake is a patented synthetic version of active compound that has been clinically proven to produce results equal to Botox® when applied topically. This exclusive formulation also features capsaicin, Matrixyl 3000®, Venuceane®, PhytoCell Tec® Malus Domestica (Swiss Apple Stem Cells), Arnica, Pomegranate Oil, Vegetable Glycerin and Witch Hazel.

Aside from using proven wrinkle fighting peptides, the new serum also incorporates PhytoCellTec Malus Domestica, Swiss Apple stem cells that are proven to reduce lines and increase skin elasticity while reversing UV damage. Venomous also uses a little known microorganism found in the deepest thermal pockets of the ocean, known commercially as Venuceane. The microorganism, Thermus Thermophilus lives in the deepest pockets of the ocean, in the most extreme thermal temperatures known to man. Venuceane has been clinically proven to stunt the aging process of skin by 5 years.



While most anti-aging products specifically target wrinkles, age spots or sagging, Venomous wrinkle serum targets all aspects of aging skin to reduce lines, sagging and discoloration while preventing deterioration – in one product. The Greensations Venomous formula does not use any chemical agents such as parabens that can trigger adverse skin conditions and it’s formulate in a base of pure vegetable glycerin. The product also uses Leucidal®, a new natural preservative that’s made from radishes and certified for organic products.


BEWARE of wrinkles products that claim to use extreme percentages of peptides above 10%. In most cases, they could not be using that amount because the cost would be astronomical and percentages over 10% generally will not become perfectly solvent in most formulations. Most importantly, using too high of a percentage doesn't help a wrinkle product work better. In fact, if you use too high of a percentage for most peptides, it can actually damage your skin. This is why the ingredient companies that create and own the patents to the most famous peptides such as Syn-Ake, Matrixyl and Argireline, generally perform clinical trials at percentages between (2% - 5%). Peptides are most effective at these percentages and they are also safe at within these ranges. Anything above the 5% range can be dangerous or just plain ineffective. In essence, too much of a good thing is not always good and that's true about anti-aging peptides. The percentages of peptides in venomous are designed at the proven levels used for clinical studies. Also - we don't use Argireline because Syn-Ake works better and Argireline can create allergic skin reactions in some people.


Ingredients: Syn-Ake® 4%, Matrixyl 3000® 3%, Venuceane® 5%, PhytoCell Tec® Malus Domestica 2.5%, Pomegranate Oil, Arnica Oil, Oleoresin Capsicum, Vegetable Glycerin, Witch Hazel, Leucidal® Liquid (Natural Certified Organic Preservative).

About The Ingredients:

Syn-Ake® is an anti-wrinkle active compound based on a synthetic tripeptide that mimics the effect of Waglerin 1, a peptide that is found in the venom of the Temple Viper, Tropidolaemus wagleri. The Syn®-Ake peptide acts by reducing muscle cell contraction, smoothing mimic wrinkles in a short period, and is reversible. This compound was awarded numerous patents and was so effective that it was also lauded by the Swiss Technology Awards, because it was proven to reduce wrinkles by up to 52% and to create a smoothing effect by up to 82% within the first few weeks of application.


Venuceane® possesses activity that mimics the anti-free radical (anti-oxidant) protective enzymes found naturally in the skin such as SOD, catalase and glutathione peroxidase. Venuceane® provides much stronger protection to the skin than more commonly known vitamin antioxidants such as Vitamin E. In fact, in vivo test showed that Venuceane® is capable of protecting against lipid peroxidation and DNA damage from UVA radiation. Not only was Venuceane shown to help to preserve the youthfulness of the skin through its anti-free radical (anti-oxidant) action, during testing it was also seen to reverse key signs of aging including wrinkles, freckles, sun spots, age spots and superficial capillaries.


Matrixyl® 3000 is an anti-aging product from Sederma. "Matrikine" is the term proposed for fragmented matrix peptides able to regulate cell activity. Matrixyl® 3000 contains two matrikines, Pal-GHK and Pal-GQPR (Palmitoyl Pentapeptide-3). Acting as messengers of cutaneous restructuration and repair, these peptides work synergistically to restore and maintain the skin's youthful appearance. Studies have demonstrated that palmitoyl pentapeptide-3 was as effective as retinol in repairing sun-damaged skin but was devoid of side-effects.


Capsaicin is the active heat component of hot peppers. It is proven to increase calcitonin gene-related peptide (CGRP) release from sensory neurons by stimulating vanilloid receptor-1 (VR-1). Since CGRP increases production of insulin-like growth factor-I (IGF-I) in fetal osteoblasts in vitro, it is possible that sensory neuron activation by capsaicin increases production of IGF-I. In one study, researchers attempted to determine whether topical application of capsaicin and related compounds increases dermal IGF-I levels and facial skin elasticity in humans. Topical application of 0.01% capsaicin to faces of 17 healthy female volunteers for seven days significantly increased cheek skin elasticity. Capsaicin also increases topical blood flow and promotes healing while reducing irritation and creating super permeability through the skin surface.


PhytoCellTec™ Malus Domestica is a liposomal preparation based on the stem cells of a rare Swiss Apple. Uttwiler Spatlauber is an endangered apple variety that was well-known for its excellent storability and thus its longevity potential. Mibelle Biochemistry has developed a novel technology enabling the cultivation of rare and endangered species like Uttwiler Spatlauber. The protection of human stem cells and anti-aging benefits produced by PhytoCellTec™ Malus Domestica has been shown by various in-vitro experiments. Other studies demonstrated its agedelaying and anti-wrinkle effects. Thus PhytoCellTec™ Malus Domestica is a revolutionary anti-aging active ingredient based on a high-tech plant cell culture technology.


Pomegranate Oil, derived from the seed of the plant, appears to cause changes in the outer layers of the skin that may help to reduce skin wrinkling and aging. A study published in the Journal of Ethnopharmacology showed that pomegranate oil stimulates keratinocytes, the major cells found in the epidermis, the outer layer of the skin. It appears that pomegranate seed oil may help to regenerate these cells and, in turn, offset the appearance of aging skin.

Arnica Oil is an effective herb which can be used to increase blood circulation around eyes. All the beauty problems, related to eyes like dark circles, puffiness, finelines, wrinkles etc. is basically due to lack of blood circulation around eyes especially due to vasoconstriction of subcutaneous blood capillaries around eyes. Arnica is clinically proven to be effective vasodilators of subcutaneous blood capillaries. Arnica promotes topical healing and facilitates the blood transport and and reduces fluid retention around eyes.

Vegetable Glycerin is beneficial for enhancing beauty through the use of cosmetics, improving the health of skin and is safe and earth-friendly. A study conducted by the Medical College of Georgia has shown that glycerin may also have therapeutic benefits to the skin (see link in References). Aside from its cosmetic value, vegetable glycerin has been studied and found to not only make skin look better, but also function better by supporting its maturation. According to the findings by Wendy Bollag, Ph.D., the vegetable glycerin works by signaling the skin cells to mature through their normal stages. Researchers claim products containing the ingredient may have a positive affect on skin conditions like skin cancers (non-melanoma) and psoriasis (a chronic and sometimes severe thickening of the skin).


Witch Hazel is well known for its soothing powers on the skin. Anytime your skin feels rough or blistered, witch hazel natural care is the perfect way to make it feel better. It can be used to both clean the skin and to soothe it, but Witch hazel is also a powerful wrinkle fighter. It contains tannins and has incredible antioxidant properties that destroy some of the free radicals that cause wrinkles, giving the skin a noticeably smoother texture. This is something that no synthetic astringent can do- it's something that many inexpensive wrinkle creams don't even do. Venomous™ is about the only wrinkle product that uses Witch Hazel.


Leucidal® Liquid is a new, natural preservative from Active Micro Systems combining the current trends for alternative preservative systems and peptide technology. Derived from radishes fermented with Leuconostoc kimchii, a lactic acid bacteria that has traditionally been used to make kimchi, this product consists of an isolated peptide that is secreted from the bacteria during the fermentation process that has been shown to have antimicrobial benefits. Leucidal® Liquid is accepted by ECOCERT as a preservative in certified organic cosmetics.