Extreme Measures loses credibility near the climax when it sacrifices its hold on reality, but this entertaining, intelligent thriller effectively applies a formulaic plot to the complicated ethics of medical research. It also gives Hugh Grant an opportunity to break free from
lightweight comedy by playing an emergency room surgeon who discovers that a renowned neurologist (Gene Hackman) has been conducting secret experiments on patients. When Grant
fails to save a patient whose body later mysteriously disappears from the morgue, his investigation leads to an underground community of healthy homeless people, some of whom have
been test subjects in Hackman's revolutionary, but criminal research toward a cure for paralysis.