Pete and Wayne grew up side by side. After Pete's mother abandoned him, Wayne's family took him in and treated him as their own son. Through adolescence, college, medical school, and in their shared orthopedics practice, Pete and Wayne have lived their entire lives as best friends - as brothers. And as brothers, they have always been rivals when it came to women. The fateful night when Carla walks into the bar where Pete and Wayne are having drinks brings Wayne his customary, more fortunate, luck with the ladies. Even though Pete spotted her first, it is Wayne who seals the deal, and soon enough, Wayne and Carla are engaged. But Wayne's need for one last conquest tempts him into bed with another woman, and the ensuing guilt lead him to confide in his best friend - a mistake that will haunt the three of them forever.